PhD position - Metabolic regulation of tissue-resident immune cells during metastasis
06.02.2025
Universitätsklinikum Bonn AöR
Bonn (DE)
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PhD position - Metabolic regulation of tissue-resident immune cells during metastasis
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Universitätsklinikum Bonn AöR
Bonn (DE)
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PhD position - Metabolic regulation of tissue-resident immune cells during metastasis
Universitätsklinikum Bonn AöR
Bonn (DE)
Aktualität: 06.02.2025
Anzeigeninhalt:
06.02.2025, Universitätsklinikum Bonn AöR
Bonn (DE)
PhD position - Metabolic regulation of tissue-resident immune cells during metastasis
Unternehmen: Universitätsklinikum Bonn AöRArbeitszeitmodell: Teilzeit - VormittagArbeitsort: Bonn (DE)Stellenbeschreibung:The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.The Tumor Immunometabolism research group led by Jun. Prof. Laura Surace at the Institute of Clinical Chemistry and Clinical Pharmacology (University Hospital Bonn Campus), Faculty of Medicine Rheinische Friedrich Wilhelms-University Bonn
invites applications for part-time (25,025h/week)
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PhD position - Metabolic regulation of tissue-resident immune cells during metastasis
We are seeking highly motivated candidates with a strong interest in immunology. Our lab is interested in better understanding the role of tissue-resident immune cells in metastasis formation. We aim to achieve this by defining tissue-specific immune subset metabolic requirements, phenotype and function and by assessing their interplay with the other components of the primary tumor and metastasis microenvironment. We specifically focus on innate lymphoid cells (ILC) and T cells (Karagiannis F*, Peukert K*, Surace L*, et al. Nature 2022*;* Surace et al. Nature Immunology 2021; Surace et al. Blood Advances 2021). For more information, please refer to the website à (https://www.ukbonn.de/ikckp/forschung/ag-surace/) https://www.ukbonn.de/ikckp/forschung/ag (https://www.ukbonn.de/ikckp/forschung/ag-surace/) - (https://www.ukbonn.de/ikckp/forschung/ag-surace/) surace/ (https://www.ukbonn.de/ikckp/forschung/ag-surace/) . (https://www.ukbonn.de/ikckp/forschung/ag-surace/) The project will investigate how changes in host metabolism shape the cellular composition and the metabolic features of the tissue microenvironment, during tumor development and metastasis. Ultimately the goal is to identify novel therapeutic strategies, including dietary intervention, that would be applicable in the treatment of metastatic cancer.
Requirements:
- Master's degree in life science (biology, biomedicine, molecular medicine or comparable studies).
- Candidates with experience in immunology, molecular or cell biology and biochemistry are specifically encouraged to apply
- Experience in laboratory techniques and the use of experimental mouse models
- Ability to work independently and in a team
- English skills
The candidate will work with mouse models and human samples applying classical immunological methods alongside cutting-edge technologies, including imaging mass spectrometry, multiplex tissue imaging, metabolomics and extracellular flux analysis. The selected candidate will have access to scientific and soft skill training through courses provided by the University of Bonn and external institutions.
We offer:
- Responsible and versatile: a job with a lot of creative freedom in a collegial team
- Secure in the future: fee according to TV-LEG13
- Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave
- Provision for later: company pension scheme
- Clever to work: Possibility of an interest-free loan to buy an e-bike
- Tailor-made education: Subsidized further education and training
- Systematic start: Structured induction
- Healthy at work: Numerous health promotion offers, free membership in UKBfit
- Employer benefits: preferential offers for employees (corporate benefits)
The University of Bonn is committed to diversity and equal opportunity. It is certified as a familyfriendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
Applications should include:
- a CV
- a cover letter outlining why you are applying
- certificates
- the contact information of two referees
Deadline à 31st of March 2025. Please send all the listed documents by e-mail to:
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Jun. Prof. Laura Surace
W1-tenure track
Institute of Clinical Chemistry and Clinical Pharmacology
University Hospital Bonn
University of Bonn
Venusberg-Campus 1
53127 Bonn, Germany
E-Mail: lsurace@uni-bonn.de
Inhalt: © Bundesagentur für Arbeit − Referenznummer: 10001-1001111626-S
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