In this project we aim to elucidate how different micromilieu factors present during malaria infection influence the parasite's virulence and development. You will apply state-of-the-art methodologies such as genome wide RNA and chromatin sequencing approaches, high resolution imaging techniques, and CRISPR/Cas9 mediated genetic manipulations to study the underlying molecular mechanisms. This will lead to a better understanding of how malaria parasites react to environmental changes and how this can be exploited for novel anti-malarial therapies.